Professor Gerard Hoyne
BSc(Hons), PhD, GCUT
Associate Dean Research – Lecturer Biomedical Science

Phone: 9433 0236

Gerard Hoyne joined Notre Dame in 2009 and was appointed the Associate Dean of Health Sciences. Gerard completed his BSc and PhD at The University of Western Australia and has previously worked at Imperial College in London and the University of Edinburgh in the United Kingdom within the field of immunology. His research work has investigated how the immune system regulates immune responses to self and foreign proteins. This has important implications in the development of autoimmune diseases such as allergy and diabetes.

He has gained research funding both in Australia and overseas over the last 20 years. He has co-authored over 50 scientific manuscripts and has presented his work at national and international scientific conferences. He was a co-founding scientist of a biotechnology company that was established in Cambridge in the UK and is a named inventor on eight international patents that have been granted.

Gerard is a member of the Australian Society for Immunology. He has also been a member of the British Society for Immunology.

Member of the Institute of Health Research Advisory Board (UNDA)

Chair of The Systems & Intervention Research Centre for Health (SIRCH) Advisory Board at ECU

Adjunct Senior Research Fellow in the Lung Institute of Western Australia
Teaching Areas
Microbiology, Immunology, Infectious Diseases
Research Expertise and Supervision
I have over 20 years experience in medical research in Australia and overseas. I undertook postdoctoral studies at Imperial College in London and the University of Edinburgh in the United Kingdom. I was a Research Fellow and Laboratory Head at the John Curtin School of Medical Research at the Australian National University in Canberra before moving to the University of Notre Dame Australia.

I have received grant funding from Wellcome Trust UK, Medical Research Council UK , NH&MRC, Juvenile Diabetes Research Foundation (JDRF), Diabetes Australia Research Trust, Western Australia Diabetes Research Foundation.

I have supervised 16 Honours students , 3 Masters students and 7 PhD students to completion.

I have examined 13 PhD theses from Australian and European universities

I am an adjunct Senior Research Fellow at the Lung Institute of Western Australia and the School of Pharmacology and Medicine at the University of Western Australia. I have served on an NH&MRC Grant review panel and regular review grants for the NH&MRC.

I have reviewed grants for the Medical Research Council UK, The Wellcome Trust UK, Diabetes Australia Research Trust, Leukaemia Foundation, Human Frontiers Science Project, St Vincent Medical Research Foundation, Sydney Medical Research Foundation, Multiple Sclerosis Society, Diabetes Australia Research Trust, FWO Flanders Belgium.

Reviewed papers for the following Journals: Nature Immunology, Immunology and Cell Biology, PLOS One, Immunology, Leukemia Research, International Archives of Allergy and Clinical Immunology, Febbs Letters – Immunology, Clinical and Developmental Immunology, Molecular and Cellular Immunology, American Journal of Clinical Immunology, International Journal of Molecular Sciences, Journal of Clinical and Cellular Immunology.

Membership of Editorial Boards
  • ISRN Immunology 2011- onwards
  • American Journal of Clinical and Experimental Immunology 2012 – onwards
  • Gnosis Journal of Clinical Immunology 2014- onwards


Research and engagement

Journal Articles and Proceedings
  • Yabas, M., Godfrey, D. Goodnow. C.C and Hoyne G.F. 2011 Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells.. PLoS One ;6(11):e26440. Epub 2011 Nov. doi: 10.1371/journal.pone.0026440.
  • Hoyne, G.F., Flening, E., Yabas, M., The, C., Altin, J., Randall, K. Thien, C.B.F., Langdon W.Y. and Goodnow. C.C. 2011.Visualizing the role of Cbl-b in control of islet-reactive CD4 T cells and susceptibility to Type 1 diabetes J. Immunol186(4):2024-32.
  • Sontani Y., Chapman, G., Papathanasiou P., Dunwoodie S.L., Goodnow. C.C and Hoyne G.F. 2011. Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL.Leukaemia Res 35 (11): 1512-1519.
  • Isomura I, Palmer S, Grumont RJ, Bunting K, Hoyne G, Wilkinson N, Banerjee A, Proietto A, Gugasyan R, Wu L, McNally A, Steptoe RJ, Thomas R, Shannon MF, Gerondakis S. c-Rel is required for the development of thymic Foxp3+ CD4 regulatory T cells. J Exp Med. 2009 Dec 21;206:3001-14.
  • Wu Z, Jia X, de la Cruz L, Su XC, Marzolf B, Troisch P, Zak D, Hamilton A, Whittle B, Yu D, Sheahan D, Bertram E, Aderem A, Otting G, Goodnow CC, Hoyne GF. Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL.Immunity.2008 29:863-75.
  • Wong, K., Carpenter, MJ., Young, L.L., Platt, AJ., Walker, SJ., McKenzie, G., Rust, AJ.,Ward, G., Packwood, L., Wahl, K., Delriviere, L., Hoyne, GF, Gibbs, P., Champion, BR., Lamb, J. R., and Dallman M.J. (2003) Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell dependent mechanism. J. Clin Invest.112: 1741-1750.
  • Papathanasiou, P, Perkins, A.C., Cobb, B.S., Ferrini, R., Sridharan, Hoyne, GF., R., Nelms, K.A., Smale, S.T., Goodnow, C.C. 2003. Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor.Immunity 19:131-144.
  • Stewart, G. Hoyne, G. F.,.Ahmad, S., Jarman , E. R., Wallace WAH, Harrison, DJ, Haslett, C., Lamb, J. R., Howie, S. E. (2003) Expression of the developmental Sonic hedgehog [Shh] signalling pathway is upregulated in chronic lung fibrosis and the Shh receptor patched 1 is present in circulating T lymphocytes J. Path 199:488-495.
  • Lowrey, J., Stewart, G. A., Lindey, S., Forsyth, L.M.G., Hoyne, G. F., Hayley, S., Lamb, J. R., Howie, S. E., (2002) Shh promotes expansion of peripheral CD4+ T cell following suboptimal TCR signalling J. Immunol. 169: 1869-1875.
  • Hoyne G.F., Le Roux I., Corsin-Jimenez M., Tan K., Dunne J., Forsyth L.M., Dallman M.J., Owen M.J., Ish-Horowicz D. & Lamb J.R. (2000) Serrate1-induced Notch signalling regulates the decision between immunity and tolerance made by peripheral CD4(+) T cells. Int. Immunol., 12, 177.
Conference Papers
Professional Affiliations
  • Member of the Australian Tertiary Education Management (ATEM) 2012 – onwards
  • Member of the ATEM Western Regional Organizing Committee 2012 - onwards
  • Member of the Australian Society of Immunology 2002- present
Community Engagement
Chair – External Scientific Advisory Board Systems and Intervention Research Centre for Health (SIRCH), School of Health Sciences, Edith Cowan University 2015- 2017

Member of the NH&MRC Grant Review Panel (Immunology) 2010.

Member of the NH&MRC Translational Faculty (Immunology) 2012- onwards.
  • Member of the Organizing Committee for the Australasian Society for Immunology Annual Conference, Perth 2010.
  • Coordinator of the Postgraduate Student Workshop ASI Meeting, Perth.2010.
  • ACT Councillor Australasian Society for Immunology 2008-2009.
  • Member of the Organizing Committee for the Australasian Society for Immunology Annual Conference, Canberra 2008.
  • Coordinator of the Postgraduate Student Workshop ASI Meeting, Canberra 2008.
  • Organizer- World Day of Immunology Celebrations- Canberra 2008 & 2009
  • 1996 Pharmacia Fellowship.
  • 1989 Australian Society of Immunology student travel award, Adelaide.
  • 1989 UWA PhD Scholarship